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Pre-implantation genetic tests (PGT)

What is the difference between Pre-implantation Genetic Diagnosis (PGD) and Pre-Implantation Screening (PGS)?

These are both pre-implantation genetics tests (PGT) done on the embryo before embryo transfer. The embryos are obtained through a process called in-vitro fertilisation (IVF).

PGS   PGD
Testing for normal chromosome numbers (23 pairs) What it involves Test for specific, known genetic disorder
1 or more cells are taken from embryo while it is still in the lab How it is done 1 or more cells are taken from embryo while it is still in the lab
To increase IVF success and reduce miscarriages What its purpose is To reduce risk of passing on the specific genetic disorder
Couples with recurrent miscarriage, low quality eggs, multiple failed IVF cycles Who it is recommended for 1 or both parent are carriers of known genetic disorder

Depending on the country, PGD and PGS are governed by different rules and regulations. You should discuss with your gynaecologist to see if you are suitable for, or require pre-implantation genetic tests.

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Dr. Ng Kai Lyn

MBBS (SG) | MMed (SG) | MRCOG (UK) | FAMS (SG)

Empowering Women's Health

This article has been medically reviewed by Dr Ng Kai Lyn
Dr Ng Kai Lyn 黄楷伶 is a Consultant Obstetrician and Gynaecologist with sub-specialty expertise in urogynaecology and minimally invasive surgery, as well as a clinical interest in fertility.
(65) 9152 4942
(65) 6635 2100
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